DomHub

Developed for both parents and professionals, DomHub is an evidence-based and fully referenced online database for all things domperidone.

One of the biggest challenges parents face with initiating and increasing milk production is understanding of and access to the pharmaceutical medication domperidone. Fortunately, everything you need to know backed by scientific evidence is now at your fingertips....

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DomHub's first module covers in detail the safety and effectiveness of domperidone for lactation:

Domperidone effectiveness at increasing milk production
Understanding the FDA warning against domperidone
Domperidone safety for lactating parents
Potential side effects
Domperidone safety for babies when their lactating parent takes domperidone
Use of domperidone in developed countries throughout the world
Domperidone compared with FDA-approved medication metoclopramide (Reglan®)
Dosage for lactation
Discontinuing domperidone safely
Ethical issues for lactation consultants

The second module is all about how to access domperidone, particularly for those in the United States.

Getting a script from your provider
How much to order at a time
Brand name domperidone (Motilium®) versus generic
Obtaining domperidone in the U.S. through a compounding pharmacy
In an emergency...getting domperidone quickly
Listing of international online pharmacies selling domperidone

DomHub encourages members to share their questions and experiences in the comments area of each section.

This creates a live and growing source of domperidone information and support shared between parents and professionals, in addition to the extensive collection of published research which serves as the foundation for DomHub.

Domperidone may or may not be a good choice for you --- or for your client if you are a lactation or medical professional. Whether or not a parent chooses to use domperidone to support their lactation journey, that decision should be an informed one.

DomHub is an organized database of evidence-based information from dozens of medical and lactation journals, personal communications with physicians and pharmacists, and parent feedback on their experiences.

"Oh my goodness, how nice to have everything in one place - what a wonderful service you provide!" - Elissa

Check out DomHub's reference list here

AAP Committee on Drugs. (2001). The transfer of drugs and other chemicals into human milk. Pediatrics, 108(3), 776-789.

Asztalos, E. V., Campbell-Yeo, M., da Silva, O. P., Ito, S., Kiss, A., Knoppert, D., & EMPOWER Study Collaborative Group. (2017). Enhancing human milk production with domperidone in mothers of preterm infants: results from the EMPOWER trial. Journal of Human Lactation, 33(1), 181-187. https://doi.org/10.1177/0890334416680176

Bazzano, A. N., Cenac, L., Brandt, A. J., Barnett, J., Thibeau, S., & Theall, K. P. (2017). Maternal experiences with and sources of information on galactagogues to support lactation: a cross-sectional study. International journal of women's health, 9, 105. https://doi.org/10.2147/IJWH.S128517

Boyce, M. J., Baisley, K. J., & Warrington, S. J. (2012). Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy volunteers: a randomized, placebo‐controlled, double‐blind, crossover study. British journal of clinical pharmacology, 73(3), 411-421. https://doi.org/10.1111/j.1365-2125.2011.04093.x

Campbell-Yeo, M. L., Allen, A. C., Joseph, K. S., Ledwidge, J. M., Caddell, K., Allen, V. M., & Dooley, K. C. (2010). Effect of domperidone on the composition of preterm human breast milk. Pediatrics, 125(1), e107-e114. https://doi.org/10.1542/peds.2008-3441

CBC News. (2012). Domperidone safety alert issued by Health Canada. Retrieved from CBC News: http://www.cbc.ca/news/health/story/2012/03/08/Domperidone-maleate-drug-.html

Co, M. A. M., Hernandez, E. A., & Co, B. G. (2002, September). A comparative study on the efficacy of the different galactogogues among mothers with lactational insufficiency. Journal of Clinical Pharmacology, 42(9), 1052-1052). https://doi.org/10.1021/np060295f

da Silva, O. P., Knoppert, D. C., Angelini, M. M., & Forret, P. A. (2001). Effect of domperidone on milk production in mothers of premature newborns: a randomized, double-blind, placebo-controlled trial. Cmaj, 164(1), 17-21.

Flanders et al. (2012). A consensus statement on the use of Domperidone to support lactation. Retrieved from Kindercare Pediatrics: http://kindercarepediatrics.ca/wp-content/uploads/Domperidone-Consensus-Statement-Final-May-11-2012.pdf

Flanders, D. (2012). The (not so) great Canadian domperidone debacle. Retrieved from Kindercare Pediatrics: http://kindercarepediatrics.ca/2012/03/the-not-so-great-canadian-Domperidone-debacle-%E2%80%93-next-steps/

Gribble, K. D., & Hausman, B. L. (2012). Milk sharing and formula feeding: Infant feeding risks in comparative perspective?. The Australasian medical journal, 5(5), 275. https://doi.org/10.4066%2FAMJ.2012.1222

Grzeskowiak, L. E., Lim, S. W., Thomas, A. E., Ritchie, U., & Gordon, A. L. (2013). Audit of domperidone use as a galactogogue at an Australian tertiary teaching hospital. Journal of Human Lactation, 29(1), 32-37. https://doi.org/10.1177/0890334412459804

Grzeskowiak, L., & Smithers, L. (2017). Use of domperidone and risk of ventricular arrhythmia in the postpartum period: Getting to the heart of the matter. Pharmacoepidemiology and Drug Safety, 26(7), 863-864. https://doi.org/10.1111/1471-0528.15177

Grzeskowiak (2022). An evidence-based guide to using domperidone as a galactogogue. GOLD Lactation.

Haase, B., Taylor, S. N., Mauldin, J., Johnson, T. S., & Wagner, C. L. (2016). Domperidone for treatment of low milk supply in breast pump–dependent mothers of hospitalized premature infants: a clinical protocol. Journal of Human Lactation, 32(2), 373-381.

Hale, T. W., Kendall-Tackett, K., & Cong, Z. (2018). Domperidone versus metoclopramide: Self-reported side effects in a large sample of breastfeeding mothers who used these medications to increase milk production. Clinical Lactation, 9(1), 10-17. https://doi.org/10.1177/0890334416630539

Hale, T. W. and Krutsch, K. (2022). Medications and mothers' milk 2023: a manual of lactational pharmacology, 20^th edition. New York: Springer.

Ingram, J., Taylor, H., Churchill, C., Pike, A., & Greenwood, R. (2012). Metoclopramide or domperidone for increasing maternal breast milk output: a randomised controlled trial. Archives of Disease in Childhood-Fetal and Neonatal Edition, 97(4), F241-F245. http://dx.doi.org/10.1136/archdischild-2011-300601

International Board of Lactation Consultant Examiners (2015). Code of Professional Conduct for IBCLCs. Retrieved from https://iblce.org/wp-content/uploads/2017/05/code-of-professional-conduct.pdf

Khorana, M., Wongsin, P., Torbunsupachai, R., & Kanjanapattanakul, W. (2021). Effect of domperidone on breast milk production in mothers of sick neonates: a randomized, double-blinded, placebo-controlled trial. Breastfeeding Medicine, 16(3), 245-250. https://doi.org/10.1089/bfm.2020.0234

Kim, P. Y., & Ewer, M. S. (2014). Chemotherapy and QT prolongation: overview with clinical perspective. Current treatment options in cardiovascular medicine, 16(5), 1-13. https://doi.org/10.1007/s11936-014-0303-8

Lixin, W., Hongcai, W., Ying, H., & Caifen, L. (2008). Clinical observation on the effects of electroacupuncture at Shaoze (SI 1) in 46 cases of postpartum insufficient lactation. Journal of Traditional Chinese Medicine, 28(3), 168-172. https://doi.org/10.1016/S0254-6272(08)60038-2

McBride, G. M., Stevenson, R., Zizzo, G., Rumbold, A. R., Amir, L. H., Keir, A. K., & Grzeskowiak, L. E. (2021). Use and experiences of galactagogues while breastfeeding among Australian women. PloS one, 16(7), e0254049. https://doi.org/10.1371/journal.pone.0254049

Mehrabadi, A., Reynier, P., Platt, R. W., & Filion, K. B. (2018). Domperidone for insufficient lactation in England 2002‐2015: A drug utilization study with interrupted time series analysis. Pharmacoepidemiology and Drug Safety, 27(12), 1316-1324. https://doi.org/10.1002/pds.4621

Moriello, C., Paterson, J. M., Reynier, P., Dahl, M., Aibibula, W., Fisher, A., ... & Filion, K. B. (2021). Off-label postpartum use of domperidone in Canada: a multidatabase cohort study. Canadian Medical Association Open Access Journal, 9(2), E500-E509. https://doi.org/10.1111/bcp.14737

Newman, J. & Goldfarb, L. (2010). Breastfeeding: The protocols for induced lactation. Retrieved from: http://www.asklenore.info/breastfeeding/induced_lactation/regular_protocol.shtml

Newman, J. & Polokova, A (2022). What doctors don't know about breastfeeding. Amarillo, TX: Praeclarus Press.

Nice, F. J. (2016). Domperidone. Retrieved from https://nicebreastfeeding.com/counseling-tips/

Shen, Q., Khan, K. S., Du, M. C., Du, W. W., & Ouyang, Y. Q. (2021). Efficacy and safety of domperidone and metoclopramide in breastfeeding: A systematic review and meta-analysis. Breastfeeding Medicine, 16(7), 516-529. https://doi.org/10.1089/bfm.2020.0360

Smolina, K., Morgan, S. G., Hanley, G. E., Oberlander, T. F., & Mintzes, B. (2016). Postpartum domperidone use in British Columbia: a retrospective cohort study. Canadian Medical Association Open Access Journal, 4(1), E13-E19. https://doi.org/10.9778/cmajo.20150067

Suain Bon, R., & Mahmud, A. A. E. (2022). Domperidone use as a galactagogue and infanticide ideation: a case report. Breastfeeding medicine, 17(8), 698-701. https://doi.org/10.1089/bfm.2022.0016

Taylor, A., Logan, G., Twells, L., & Newhook, L. A. (2019). Human milk expression after domperidone treatment in postpartum women: a systematic review and meta-analysis of randomized controlled trials. Journal of Human Lactation, 35(3), 501-509. https://doi.org/10.1177/0890334418812069

United States Food & Drug Adminisitration (2016). FDA talk paper: FDA warns against women using unapproved drug, domperidone, to increase milk production. Retrieved from https://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm173886.htm

West, D., & Marasco, L. (2009). Is Domperidone safe and can it be obtained legally in the US? Retrieved from Low Milk Supply: http://www.lowmilksupply.org/Domperidone-safe.shtml

Wight, N. E. (2011). Domperidone for improving breastmilk production. Retrieved from San Diego Breastfeeding Coalition: http://www.breastfeeding.org/uploaded_files/bf_meds/Domperidone_Patient_Handout.pdf

A note from DomHub developer ALYSSA SCHNELL, IBCLC

"Hello! My name is Alyssa and I have been working as a board-certified lactation consultant since 2009. I have supported thousands of parents to induce lactation, relactate or increase milk production ... oftentimes with the help of domperidone.

And, personally I understand what it is like to make the decision whether or not to use domperidone. I am an adoptive mom who induced lactation using domperidone. At first, I was completely against the idea! I prefer not to use pharmaceutical medications and at the time I started inducing lactation I had not used a non over-the-counter pharmaceutical medication for 15 years. I was naturally very hesitant to use domperidone just like many of you.

The difference between my experience and yours is that I hope you will have so much more information to go on as you make a decision regarding domperidone for your greatest well-being and that of your precious little one."

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